*General supplement information is listed below in accordance with the National Institute of Health dietary supplement fact sheets, unless otherwise noted (a)
Vitamin B6 – An essential vitamin that supports the central nervous system and the metabolism process, helping to convert food into energy, and aiding in the creation of red blood cells and neurotransmitters. Since the body requires vitamin B6 to create Serotonin, the neurotransmitter responsible for regulating mood, low levels have been associated with depression (1)
Form: Pyridoxal 5’-phosphate is a coenzyme, and the most active form of vitamin B6
Magnesium – An essential mineral required in bone development, nerve function, blood glucose control, and blood pressure regulation. Certain forms may impact the nervous system, promoting relaxation and sleep. Certain forms may impact the nervous system, promoting relaxation and sleep.
Form: L-Threonate has unique neurological bioavailability characteristics and enhance synaptic plasticity critical to memory and communication (3)
Carnitine – Carnitine is an amino acid derivative and plays a critical role in energy production by transporting fatty acids so they can be oxidized (“burned”) in addition to removing toxic compounds from cells, preventing their accumulation.
Form: Acetyl-L-carnitine is the acetylated form of L-carnitine. It is able to cross the blood brain barrier and supports nerve function, memory, focus and alertness. High doses may reduce blood pressure, and peripheral neuropathy (reduces neurodegeneration) (4)
Alpha-Lipoic Acid – An antioxidant found in many multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age (5)
Form: Na-R-ALA is a bio-enhanced, stabilized version of the active form of ALA (R-ALA), which doesn’t degrade as easily and is more bioavailable and easily absorbed in the body.
Docosahexaenoic Acid – This polyunsaturated fatty acid is essential for the growth and functional development of the brain in infants and is also required for maintenance of normal brain function in adults. DHA has an anti-inflammatory effect on nerve cells, indicating it may play a role in reversing age-related impairment of memory acquisition or in reducing the symptoms of depression and/or anxiety disorders. (6) (7)
Form: Docosahexaenoic Acid (DHA) 32+2% is a patented form, sourced from algae
Phosphatidylserine – A phospholipid required for healthy nerve cell membranes and myelin. Supports cognitive functions of memory formation, consolidation and retrieval, focus, attention, and concentration. May enhance athletic performance and recovery as it supports rapid reactions/reflexes and locomotor functions (8)
Exogenous PS is easily absorbed in the body and may slow or reverse structural deterioration in nerve cells.
Curcumin – A polyphenol derived from the curcuma longa plant (tumeric), with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties and inhibits other enzymes involved in inflammation. There is some evidence that it may work as an anticancer, antibiotic, anti-inflammatory, and anti-aging agent (9) (10) and may improve cognitive functions such as working memory and sustained attention (11)
Form: Form: Longvida Curcumin Extract is an optimized and highly bio-available form of Curcumin.
Berberine – A plant alkaloid often taken for diabetes, high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), and high blood pressure. It affects the body on a molecular level, activating the enzyme AMPK (adenosine monophosphate-activated protein kinase), often called the “metabolic master switch”. May support wellbeing, energy, mood (12) and balanced inflammation levels. (13)
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